DNA and RNA are both nucleic acids, but they have several differences in their structure, composition, and function. DNA is a double-stranded molecule found in the nucleus of a cell, while RNA is a single-stranded molecule that can be found in both the nucleus and cytoplasm of a cell. The major difference between the two is that DNA contains the base thymine, while RNA contains the base uracil. Additionally, DNA is a stable molecule that is used to store genetic information, while RNA is a transient molecule that is used to translate genetic information. Lastly, DNA is used to replicate a cell’s genetic information, while RNA is used to express genetic information in the form of proteins.